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  • Note that the antagonist impaired the wheel test-induced locomotion and W only in the Ox+/+ mouse (compare b with A).Orexin/Hypocretin and Histamine: Distinct Roles in the Control of Wakefulness Demonstrated Using Knock-Out Mouse ModelsJ Neurosci. ;29(46):14423-14438.Figure 7Comparison of the effects of a wheel test, alone or combined with pharmacological dosing, on the locomotion and sleep-wake s
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