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  • Non-Classical CAH or 21 Hydroxylase Deficiency is the most common genetic disease known, occurring in 1% of New Yorkers, and up to 3% in ethnic groups such as of Ashkenazi Jews, Hispanics, Italians, and Yugoslavs.(68) Ten per cent of patients with PCOS actually have Non-Classical CAH. The underlying genetic defect causes an enzyme deficiency in the adrenal gland which reduces the ability of the ad
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