Other causes, such as cancer that spreads () to the bone, may be less obvious.Common CausesBone pain can occur with injuries or conditions such as:Cancer in the bones (primary malignancy)Cancer that has spread to the bones (metastatic malignancy)Disruption of blood supply (as in sickle cell anemia)Infected bone (osteomyelitis)InfectionInjury (trauma)LeukemiaLoss of mineralization (osteoporosis)Ove