proinflammatory cytokines such as interleukin-1 (IL-1), IL-6, and tumor-necrosis-factor-?? (TNF-??); chemokines including monocyte chemotactic-1 (MCP-1) and macrophage inflammatory protein-1 (MIP-1); complement components; free radicals such as reactive oxygen species (ROS), including superoxide anions and hydroxy radicals [4, 5].