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  • Disease symptoms include lethargy, depression, failure to concentrate, anorexia, sleep disturbances, reduction in personal hygiene or social withdrawal, and are mediated by proinflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor ?? (TNF??) [1].Previous research has suggested that these specific monocyte-derived cytokines are increased in the peripher
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