Expression of CYP27B1 and CYP24A1 is not limited to the kidneys, but is found in various tissues including breast and prostate, as well as colon.6 Extra-renally produced 1,25-D3 acts in an autocrine/paracrine manner5 and is considered to be anti-tumorigenic by regulating cell proliferation, apoptosis, angiogenesis and differentiation.7,8 The 1,25-D3 catabolizing enzyme CYP24A1 is overexpressed in