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  • The synthesis of a compound of Formula P1 (Scheme 7), such as methyl 2-cyclopropyl-6-(trifluoromethyl)nicotinate, wherein R37 is a group as defined for R11, especially an alkyl group that may be optionally substituted with 1 to 3 R12, may be accomplished according to E. Okada, et al., Heterocycles, volume 46, pp. 129-132, 1997 by reaction of (Z)-4-amino-1,1,1-trifluorobut-3-en-2-one with a methyl
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