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  • The studies have identified that Pb deposit in astrocytes competitively with copper (Cu) binds to heavy metal binding (HMB) domain of ATP7A, a Cu-transporting ATPase that contributes to Cu release, leading to Cu accumulation intracellularly and the promotion of reactive oxygen species (ROS) production that both have been involved in neurodegenerative diseases including Alzheimer???s disease and am
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