Humans can be treated with the compounds of the invention and fall within the mammal sub-category. [0038] As used herein, the term ???CAAX??? means a C-terminal peptide sequence wherein C is Cys, A is an amino acid, usually an aliphatic amino acid, and X is another amino acid, usually Leu or Phe. [0039] As used herein, the term ???CAAX protein??? means a protein comprising a CAAX sequence. [0040]