Referring to FIGS. 6-9, when the clip applying device 50 is loaded with a cartridge 68 a, 68 b, there is a predetermined distance Da, Db between the proximal bearing 76 and distal bearing 74, this distance being determined by a stop key 13 located in the enclosure barrel 72. [0029] When the clip cartridge 68 b is inserted into the receiving slot or port 70 of the clip applying device 50, the cartr