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  • angliosides and glycosaminoglycans, including HS, dermatan sulfate and hyaluronic acid, in various organs of suramin-treated patients and animals.18 Certainly, because heparanase is the major endoglycosidase initiating the sequential cleavage of HS linked to ECM HSPG, its inhibition is much more critical in tumor metastasis than the inhibition of exoglycosidases and/or sulfatases.We have considere
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