d no oc-currence of progressive disease, and progressive disease as any new lesion or an increase of at least 50% in the sum of the product of diameters of previously involved sites.25 An independent review facility (RadPharm) retrospectively evaluated the radiographic scans.Cytokines and chemokines, including tumor necrosis factor ?? (TNF-??), interleukins (1??, 2, 6, and 8), granulocyte???macrop