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  • In the caseof HCV, patients infected with HCV uniformly have increased expression of the TRAIL onhepatocytes [26].Interestingly, a major effect of IFN-?? treatment is the enhanced expression of TRAIL byeffector cells of the immune system, including T cells and natural killer (NK) cells [27] andhigh level of TRAIL expression by NK cells is associated with therapeutic clearance ofHCV [7].
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