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CpG DNA may induce the secretion of Th1 cytokines such as IL-12 and IFN-??, as well as proinflammatory cytokines including tumor necrosis factor TNF-??, IL-6 and type I IFN. Klinman D M et al. (1996) Proc Natl Acad Sci USA 93:2879-83.
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