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Etiologic factors involved include not only genetic predisposition, but also lifestyle and dietary changes (e.g. high-fat, high-caloric diets and lack of exercise leading to obesity, increased risk of diabetes and coronary artery disease) and exposure to occupational, recreational and environmental toxins and pollutants, particularly alcohol and smoke (WHO/ICBDMS/EUROCAT, 1998, WHO, 1999).
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