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In the schizophrenia arena, clozapine and several other antipsychotics are 5-HT2AR antagonists, which leads Schmid et al. to conclude that their work ???could have major implications in drug development for treating neuropsychiatric disorders such as depression and schizophrenia.??? They note that clozapine induces 5-HT2AR internalization but not ERK activation in several systems, and speculate th
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