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In one aspect, a fluid is provided which comprises an agent such as a chemotherapeutic agent, radioactive agent, radiosensitizer, a trophic factor (e.g., a neurotrophic factor), antibiotic, hormone, steroid, growth factor, neurotransmitter, an agonist, or antagonist of a neurotransmitter, a symphathomimetic, a metabolite, cell (e.g., such as a stem cell), sedative, anti-epileptic (e.g., acetzolami
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