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ACE: Angiotensin-converting enzyme; AT1: Angiotensin II type 1 receptor; AT2: Angiotensin II type 2 receptor; AT4: Angiotensin II type 4 receptor; MAS: Mas receptor; RAS: Renin-angiotensin system.Besides circulating RAS, local RASs also exist in various organs and tissues, such as the heart, blood vessels, kidney, liver, pancreas, intestine, nervous system, reproductive system, as well as lymphati
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