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In assessing change in BMI, observational studies must be careful to minimize confounding by factors such as smoking status, physical activity, (Rosengren et al., 1999) and potential underlying malignancy (Wannamethee et al., 2002).The objective of this study was to use prospective data from a large cohort with long-term follow-up to better understand how change in BMI is associated with risk of C
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