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n amount sufficient to absorb the laser energy, convert the radiation to heat, and melt the stopper material, e.g., to a depth equal to at least about ??? to about ??? of the depth of the needle hole, within a time period of less than about 2 seconds, or less than about 1.5 seconds, or even less than about 1 second; and (iv) a lubricant, such as a mineral oil, liquid silicone, or silicone oil as d
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