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least about 50%, at least about 60%, at least about 70%, at least about 80%, at least about 90%, at least about 2-fold, at least about 3-fold, at least about 4-fold, at least about 5-fold, or more, compared to the level of the MMP mRNA and/or enzyme in lung tissue from an individual not treated with the TLR agonist. [0055] In some embodiments, an effective amount of a TLR agonist is an amount that
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