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If leaving groups other than bromine are desired, the bromination step may be followed by a substitution of the bromine with other leaving groups such as Cl, F, I, OCOR, OH, OSO2 CH3, OSO2 C6 H4 CH3 -p, OR, OCONHR, and OCONHCH2 CH2 R. It is believed, however, that the alkyl arm carrying the leaving group can only be placed on the B ring of the 1,4-naphthoquinone derivative.
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