. . . . "essor that functions through deacetylation of histones and non-histone proteins.Sirt1 deacetylase activity has also been implicated in the repair of DNA damage, through its ability to deacetylate the tumor suppressor p53 [26,52], a sequence-specific transcription factor that regulates processes such as the cell cycle, cell death, and DNA repair, in response to a variety of stress signals." . .