. . . "Hypoxia and Hypoxia-inducible factor (HIF) in the microenvironment are the most important factors driving angiogenesis, tumor cell proliferation, cell survival and progression, metastatic spread, and apoptosis [11].There are two major way of blocking the VEGF pathways blocking the activation of extracellular part of VEGF receptor by inhibiting antibodies against VEGF molecule or blocking the activ" . . .