"Caution should be used in administeringenzalutamide to patients with a history of seizure or who have otherpredisposing factors, including underlying brain injury, stroke, brainmetastases, or alcoholism, or to patients receiving concomitant medicationthat may lower the seizure threshold, say the authors.The study was funded by Medivation and Astellas Pharma GlobalDevelopment." . . . . .