. . . . "Because of the fever and other flu-like symptoms associated with Alferon N Injection?? (See ADVERSE REACTIONS), it should be used cautiously in patients with debilitating medical conditions such as cardiovascular disease (e.g., unstable angina and uncontrolled congestive heart failure), severe pulmonary disease (e.g., chronic obstructive pulmonary disease), or diabetes mellitus with ketoacidosis" .