. . "Insulin resistance is a known risk factor for developing cardiovascular disease and T2DM. It is possible that carriers of the Ala allele may have a decreased risk for developing cardiovascular disease and T2DM. Consistent with this hypothesis, some studies [35]???[38] also showed that the PPAR??2 Ala12 allele contributed to a reduced cardiovascular risk profile or coronary heart disease, in additi" . .