. . . " n is an evenly spaced time interval; and y is an analyte concentration or signal converted to an analyte concentration which signal measurement is optimized to fit the results sought, e.g., to correspond with a reference analyte concentration (see, for example, U.S. Pat. No. 6,272,364, issued 7 Aug. 2001; WO 99 58973, published 18 Nov. 1999; both herein incorporated by reference in their entireti" .