"The DNA may be coated onto gold microparticles, and delivered intradermally by a particle bombardment device, or ???gene gun??? as described in the literature (see, for example, Tang et al. (1992), Nature 356:152-154), where gold microprojectiles are coated with the DNA, then bombarded into skin cells. [0284] In yet other embodiments of the invention, the active agent is an agent that modulates, a" . . . . .