"This underscores the difficulty of accounting for the data without any ad hoc assumptions unless one considers processes, such as washing, which allow for variations in Ip from probe to probe.Variant 3 of Model I Next we investigate the importance of allowing Kd to vary with probe sequence, by considering a variant???Variant 3???wherein the parameters ????(b1,b2), a, Iprobe and ?? are derived from" . . . .