. . . "Clearance of P-gp substrates was decreased, however, throughout the body, including via the liver, kidneys and intestines, implying global suppression of P-gp function during AKI. The effect of AKI on P-gp suppression may impact on clearance of drugs such as Digoxin, Methotrexate and Vincristine [80].The organic anion transporters (OATs) and organic cation transporters (OCTs) are important in tran" . .