"ubstituted or substituted with fluorine atom, bromine atom, chlorine atom, OCH3, CF3, OH, C1-C6 alkyl; (5) a heterocyclic ring system having at least one nitrogen atom bonded directly to the carbocyclic ring of formula I and a group Z which is a carbon atom, NR8, oxygen atom, or sulfur atom wherein R8 is a hydrogen atom, C1-C6 alkyl, CO2H or CO2C1-C6 alkyl; substituent D1 is a 9-15 membered hetero" . . . .