. . . "Hereditary links are suggested by the occurrence of renal cell carcinomas in patients with genetic kidney conditions and diseases, including horseshoe kidneys, polycystic kidney disease, and von Hippel-Landau (VHL), an autosomal dominant disease associated with abnormalities of the VHL gene on the short arm of chromosome 3 and manifested by visceral cysts, benign masses, and the development of ren" . .