"e issues other than fertility were experienced by many woman ....some even after only one shot. the longer you are on it the stronger the effects get over time. i was put on clomid to jump start my overies....it helped. i had a stange cycle and found out i m/c that month. depo has a high risk of m/c if you conceive shortly after stopping the shot....it makes you progesterone deprived and progester" . . . .