. . . . "Gastrointestinal problems, including constipation and abdominal pain, are also common concerns [2,22].Pubertal onset and sexual development are usually normal in trisomy X, however, there have been cases of ovarian or uterine dysgenesis described in children and young adults with trisomy X. Premature ovarian failure (POF) is a condition in which the ovarian functions of hormone production and oocy" .