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  • B vitamins such as folate, vitamin B6, and vitamin B12 play important roles as coenzymes in 1-carbon metabolism, which is critical for nucleotide synthesis and DNA methylation.2 Aberrations in nucleotide synthesis or DNA methylation can contribute to carcinogenesis.3 Among the nutrients involved in 1-carbon metabolism, vitamin B6 is a crucial coenzyme in the conversion of tetrahydrofolate to 5,10-
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