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  • Most desirably, X is S, X is C, W is C, Y is C, Z is C, R6 is a halogen, and T is C(OH)R1R2, where R1 and R2 are hydrogen, R3 is H, R4 is a lower alkyl of S-stereochemistry, and R5 is H. In preliminary screening assays in vitro and in vivo, compounds of these structures have been found to have unexpectedly good beta-amyloid inhibitory activity, and in many cases, better activity than compounds of
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