ore functional groups (such as cyano, hydroxy, alkoxy in particular methoxy or ethoxy, alkylthio in particular methylthio, COOalkyl such as COOCH3), or aryl optionally substituted with a functional group as defined above (in particular in relation to R83 or R84 themselves, or an optionally substituted heterocyclic group such as N-methyl pyrrole. [0165] When R83 and R84 is optionally substituted cy