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  • To address the CNS penetration problem, Duo and colleagues (2009) are developing nanoparticle delivery of HAART. Targeted delivery of antiretroviral drugs to CD4+ T-lymphocyte cells and macrophages as well as delivery to the brain and other organ systems could ensure that drugs reach latent reservoirs, allowing delivery of the medication to where it is needed (Mamo et al., 2010; Vyas, Shah, & Amij
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