Not surprisingly, subunit exchange increases with temperature, and is highly sensitive to changes in ionic and other conditions, which could tune the exchange rate in vivo, making suboligomeric forms available for substrate binding.Figure 4A model for the chaperone mechanism of sHSP/??C proteins. (i) sHSP/??C oligomers (here wheat Hsp16.9, 1GME) are dynamic structures that continually release and