Host cells include eukaryotes include e.g. mammalian, insect, plant, avian, yeast; and prokaryotic e.g. E. coli, B. subtilis, etc. [0075] RNA-phage: As used herein, the term ???RNA-phage??? refers to RNA viruses infecting bacteria, more specifically to single-stranded positive-sense RNA viruses infecting bacteria. [0076] Self antigen: As used herein, the term ???self antigen??? refers to molecules