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  • No clearly established facts in the record controvert the scientific facts informing Dr. Miller's reasoning: the carcinogenicity of nickel and cadmium and their capacity to reach the colon; the unique characteristics of small-cell carcinoma and its relative rarity in the colon;19 the linkage of small-cell carcinoma to toxins such as nickel and cadmium; and the genetic-alteration mechanism associat
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