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  • , CF3, OH, or C1-C6 alkyl; (5) a heterocyclic ring system having at least one nitrogen atom bonded directly to the carbocyclic ring of formula I and a group Z which is a carbon atom, NR8, oxygen atom or sulfur atom wherein R8 is a hydrogen atom, C1-C6 alkyl, CO2H or CO2C1-C6 alkyl; substitutent D1 is a 9-15 membered heterocyclic system comprising a heteroaryl ring system having at least one hetero
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