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  • Possible candidate genes have been reported in isolated reports, as have other factors, such as primary and secondary mitochondrial dysfunction and exposure to known teratogens, including gestational diabetes, maternal smoking, alcohol, and lead exposure in pregnancy [Nora et al., 1978; Czeizel and Lud??nyi, 1985; Levine and Muenke, 1991; T??zel et al., 2007; Zhao et al., 2007; Castori et al., 200
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