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  • In the non-CYP3A4 expressing cells lines, a substantial reduction cytotoxic activity is found for Compound 1.1 Results of this nature suggest that Compound 1.1 is relatively safe in cells/organs which do not express CYP3A4 activity, but that its cytotoxic activity is unmasked in cells or organs such as the liver which express CYP3A4 activity.
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