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  • Once ECs expressing TF are exposed to plasma, prothrombinase activity is generated and fibrin is formed on the surface of the cells.133 This implies that ECs express binding sites for factors IX, IXa, X, and Xa; thrombin; and fibrin.134 Yet, the identity and location of most of these binding sites is unknown, as is their role in either physiologic hemostasis or in thrombosis.
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