Ester derivatives of 19-hydroxyandrost-4-ene-3,17-dione and bis-ester derivatives of 17??,19-dihydroxyandrost-4-en-3-one are prepared by reacting the corresponding 19-hydroxy or 17??,19-dihydroxy compound with an appropriate acid anhydride of the formula ##STR7## or acid chloride of the formula ##STR8## wherein R4 is an alkyl group of from 1 to 20 carbon atoms and is straight or branched, a cycloa