Finally, the tablet is coated with from about 5% to about 10% w/w of Eudragit L100 containing 10 mg of omeprazole and optionally a buffering agent and other additives (e.g., 6% Eudragit L100, 10 mg of omeprazole, 1% triethyl citrate, and 3% talc in a 71:29 mixture of ethyl alcohol:water) to obtain the multiple-pulsated drug release tablet of the present invention.