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  • The SVCTs have limited capacities, as they tend to decrease in number the more vitamin C is accumulated in cells, and with increasing concentrations of the vitamin in circulation.[38] SVCT1 is mostly found in the liver and the kidneys (worthy of note, these are the two sites for vitamin C synthesis in the animal kingdom); SVCT2 dominates in the brain, skeletal muscles, and the spleen.[39]
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