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  • wherein R13 is a hydrogen atom, a cycloalkyl having 3 to 8 carbon atoms, or a lower alkyl, and further said --(CH2)p -- and --CH???CH--(CH2)q -- groups having optionally 1 to 3 substituents selected from a lower alkyl having optionally a hydroxy substituent, a lower alkoxycarbonyl, carboxy, hydroxy, oxo, a lower alkanoyloxy having optionally a halogen substituent, an amino-lower alkyl having optio
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